Doctor considers that Pyrogenium is related to Calcarea sulphurica. Calcarea sulphurica, she says, is given in some of the books, notably in Kent’s, as one of the great remedies for those cases where the seemingly indicated remedy does not act and for those cases which need to be followed with a deeper influence. Calcarea sulphurica for instance is one of the rare remedies which has hilarity in its mental make-up, particularly towards twilight at 6 p.m. Pyrogenium too, in its first stages, together with loquacity, has great gaiety.

Moreover, of course, Pyrogenium has a tendency to septic abscesses and is a magnificent remedy for crops of boils which can be traced back to prodromes of blood poisoning in the past. Also in peritonitis, if one has the temerity to prescribe before sending for the surgeon, Pyrogenium will often be called for, as will Calcarea sulphurica, where there has been a vent for the pus and where it keeps forming and coming in large quantities long beyond the time when healing should be present.

There are also certain respiratory analogies between Pyrogenium and Calcarea sulphurica. For instance, they both have lung abscess and some of the many symptoms agree fairly well. Pyrogenium has the strange keynote as if the heart pumped cold water, whereas Calcarea sulphurica has as if the bronchial tubes were pumped full of hot water. They also have in common a slight symptom of the head — the sensation of a cap on the head.

Think of these two remedies, Pyrogenium and Calcarea sulphurica, when you find cases in the spheres of the respiratory, gynaecological, or dermatological diseases which have any of these symptoms.

Septicaemin (B. Sanderson says bacteria and pus cells produce the same chemical result. Pyrogenium and Septicaemin may therefore be identical, but I think it best to keep them distinct)
Uterine haemorrhage, Ipecac (“if Ipecac fails when indicated give Pyrogenium”, Yingling).
Throbbing headache, Bell.
Varicose, offensive ulcers of old persons, Psor.
Skin ashy, Sec.
Suppuration, Hep.
Echi., Carb-an, Ars., Lach., Rhus-t., Bapt.
Sepsin — a toxin of Proteus vulgaris, prepared by Dr. Shedd, same symptoms as Pyrogenium of which it is the main constituent.

Malar (the vegetable Pyrogenium); Lach.
In typhoid with soreness, bed feels hard, Bapt., Arn., Rhus-t.
motion and stretching limbs, Rhus-t.
Cough worse by motion and in warm room, Bry.
Offensive diarrhea, Psor
Black stools, Lept.
Constipation, Op., Sanic., Plb.
Lochia thin, fetid, Nit-ac.
Vomits water as soon as warm in stomach, Phos.

With Baptisia:
The symptoms are much like Baptisia, but if the temperature rises very high, Baptisia will not meet the conditions so well as Pyrogenium.
With Belladonna:

Pyrogenium does not often resemble Belladonna but it can have a red face and an intensely hot skin. Pyrogenium usually differs from Bell in being more mentally alert and there is less delirium. In fact, Pyrogenium has more often to be differentiated from the Phosphorus group.

Sometimes in severe infections such as peritonitis or osteomyelitis the distinction may be virtually impossible. Fortunately the two are complementary and may be prescribed alternately — a justifiable procedure in such circumstances. Other differences between Pyrogenium and Bell are that Pyrogenium may be very restless and have offensive odours — features geniumrarely found in Bell.